Tissue Engineering of the Skin ele皮肤的组织工程等.uri.pptVIP

* * * * * * * * * * * * * * * * BURN TREATMENT AND TISSUE ENGINEERING OF THE SKIN Presentation By: Cara Nunez BACKGROUND Skin: Epidermis Dermis Hypodermis/Subcutaneous Layer Functions of the Skin: 1. Protect the body 2. Sensation 3. Heat Regulation 4. Control of Evaporation 5. Absorption 6. Water resistance 7. Storage/Synthesis 8. Aesthetics/Communication BURNS Burns are generally classified by depth The time they take to heal are directly related to the depth of the burn 1st and minor 2nd degree burns are painful Serious 2nd degree and 3rd degree burns do not hurt because the nerve endings are destroyed BURNS (CONT.) 1st Degree Only epidermis Healing time is 1 week or less 2nd Degree Epidermis + Dermis Healing time – several weeks, deeper burns take longer 3rd Degree Epidermis, Dermis and Subcutaneous layers Healing time – many weeks, usually requires excision and grafting and can cause complications including amputation and loss of life HISTORY OF BURN TREATMENT The overall goal of burn treatment is to fully heal the skin with minimal scarring and full functionality, while also managing the patients pain Mankind has been trying to heal burns since the discovery of fire Ebers Papyrus (1500 BC) lists a mixture of cattle dung and black mud as “just what the doctor ordered” for burns HISTORY (CONT.) For many years there was very little consensus on how to treat burns Fabricius Hildanus, a German Physician, first classified burns into three degrees in the 1600s After World War I the preferred treatment was surgical skin transplantation → Less scarring than before HISTORY (CONT.) Wide use of firebombs in the Korean war of the 1950s The U.S. Army Burn Center in San Antonio, Texas makes it a standard to skin graft patients with 30% or more total body surface area burns HISTORY (CONT.) The new standard of treatment became to excise the necrotic tissue and replace it with grafts of healthy skin, usually taken from the patients legs This is effective, but the patient is sti