口服左旋肉碱与卵胞浆内单精子注射治疗男性严重少、弱精子症的临床探讨.docVIP

口服左旋肉碱与卵胞浆内单精子注射治疗男性严重少、弱精子症的临床探讨 　　[摘要] 目的 探讨口服左旋肉碱与卵胞浆内单精子注射治疗男性严重少、弱精子症的临床疗效。 方法 整群选取2012年2月―2014年5月在医院收治的72例男性不育症的患者， 将其作为临床研究对象，采用随机的方式分为实验组36例和对照组36例，实验组实行ICSI治疗前，前3个月男方服用口服左旋肉碱，对照组不服用左旋肉碱。对治疗后两组受精率、优质胚胎率、临床妊娠率进行分析。 结果 经统计分析，实验组的受精率29（80.55%）、优质胚胎率17（47.22%）、临床妊娠率12（33.33%）均比对照组21（58.33%）、9（25.00%）、9（25.00%）的高，差异有统计意义（P0.05）。 结论 口服左旋肉碱与卵胞浆内单精子注射可明显提高男性精子的受精率与临床妊娠率，可以选择性作为临床辅助治疗男性不育症，值得临床推广应用。 　　[Abstract] Objective To investigate the clinical effect of oral administration of L-carnitine and intracytoplasmic sperm injection （ICSI） in the treatment of male patients with severe oligospermia and asthenospermia. Methods 72 males with infertility admitted in a hospital from February 2012 to May 2014 were selected as the clinical subjects and randomly divided into the experimental group and control group with 36 cases in each. Three months before the ICSI， the experimental group took L-carnitine orally， while the control group did not. The fertility rate， high-quality embryo rate and clinical pregnancy rate of the two groups were analyzed after treatment. Results The result of statistical analysis showed that the fertilization rate was much higher in the experimental group than in the control group [29（80.55%） vs 21（58.33%）]， P0.05； the high-quality embryo rate was also significantly higher in the experimental group than in the control group[17（47.22%） vs 9（25.00%）]， P0.05； the clinical pregnancy rate was obviously higher in the experimental group than in the control group [12（33.33%） vs 9（25.00%）]， P0.05. Conclusion Oral administration of L-carnitine and ICSI can significantly improve the fertility rate and clinical pregnancy rate， which can be selected as an adjunctive therapy for the males with infertility. And it is worthy of clinical application and promotion. 　　[Key words]近几年来，伴随着社会生活压力的加大与生活环境与饮食物的极大改变，男性少精、弱精的患者日益增多，导致男性生育能力严重下降，由于此病的特殊性，多数男性很少去医院接受治疗，导致临床治疗错综复杂。目前在临床上取得明显效果的左旋肉碱与卵胞浆内单精子注射（in-tracytoplasmic sperm injection，ICSI）被大多数医院科室采用，关于左旋肉碱与卵胞浆内单精