苏拉明复合粘弹剂对鼠眼后发性白内障的影响.docVIP

苏拉明复合粘弹剂对鼠眼后发性白内障的影响 　　【摘要】 目的 通过动物试验观察苏拉明复合粘弹剂与5-氟尿嘧啶（5-Fu）眼内灌注对大鼠后发性白内障的影响。方法 30只健康大鼠制作白内障大鼠模型， 随机分成空白对照组、苏拉明组、5-Fu组， 每组10只。行超声乳化白内障吸除术， 术中分别应用普通粘弹剂、浓度为300 μg/ml苏拉明复合粘弹剂及浓度为0.2 mg/ml的5-Fu， 观察术后大鼠后囊膜混浊情况。结果 苏拉明复合粘弹剂及5-Fu均能对鼠眼后发性白内障起到抑制作用， 但苏拉明的作用更确切、疗效更好， 长期效果更明显， 前房反应仅限于房闪（+）， 且在术后第3天完全消失， 不会对眼部产生不良影响。术后第6个月， 苏拉明组后囊混浊眼发生率10%低于空白对照组60%及5-Fu组40%， 差异均有统计学意义（P0.05）。结论 苏拉明复合粘弹剂较5-Fu能更好的预防后发性白内障。 　　【关键词】 苏拉明复合粘弹剂；5-氟尿嘧啶；后发性白内障 　　DOI：10.14163/j.cnki.11-5547/r.2016.27.193 　　【Abstract】 Objective To observe influence by suramin composite viscoelastic agent and 5-fluorouracil （5-Fu） through intraocular irrigation on rat posterior capsular opacification. Methods A total of 30 healthy rats as cataract rat model were randomly divided into blank control group， suramin group and 5-Fu group， with 10 rats in each group. They all received phacoemulsification， along with respectively applied normal viscoelastic agent， suramin composite viscoelastic agent by 300 μg/ml， and 5-Fu by 0.2 mg/ml. Postoperative posterior capsular opcaification condition was observed. Results Suramin composite viscoelastic agent and 5-Fu showed inhibiting effects on rat posterior capsular opacification， while suramin had more precise effect， better curative effect and more obvious long-term effect. Anterior chamber response was strictly limited as aqueous flare （+）， which completely disappear in 3 d after operation， without any adverse effect on eyes. In postoperative 6 months， suramin group had lower incidence of eyes with posterior capsular opcaification as 10% than 60% in blank control group and 40% in 5-Fu group. Their differences all had statistical significance （P0.05）. Conclusion Suramin composite viscoelastic agent provides better prevention than 5-Fu for posterior capsular opacification. 　　【Key words】 Suramin composite viscoelastic agent； 5-fluorouracil； Posterior capsular opacification 　　白内障是我国第一大致盲性疾病， 目前， 我国白内障患者已经超过500万， 急需手术治疗的接近200万， 每年新增的白内障人数40万～60万。据不完全统计， 在60～69岁人群中约25.97%的人患白内障，