雄激素受体、磷酸化蛋白激酶B在三阴性乳腺癌中的表达及意义.docVIP

雄激素受体、磷酸化蛋白激酶B在三阴性乳腺癌中的表达及意义 　　[摘要] 目的 探讨雄激素受体（AR）、磷酸化蛋白激酶B（P-PKB）在三阴性乳腺癌中的表达及意义。 方法 收集2012年3月～2015年3月惠州市中心人民医院收治的乳腺癌患者115例，其中三阴性乳腺癌54例，非三阴性乳腺癌61例。采用免疫组化S-P法检测AR、P-PKB表达。比较三阴性乳腺癌和非三阴性乳腺癌AR、P-PKB表达阳性率，分析三阴性乳腺癌组织中AR和P-PKB表达与临床病理参数的关系。 结果 三阴性乳腺癌AR阳性表达率明显低于非三阴性乳腺癌（P 0.05）；三阴性乳腺癌P-PKB阳性表达率明显高于非三阴性乳腺癌（P 0.05）；三阴性乳腺癌组织中AR的表达与临床分期和淋巴结转移情况呈显著负相关（r = -0.295、-0.311，P 0.05）；三阴性乳腺癌组织中P-PKB的表达与临床分期和淋巴结转移情况呈显著正相关（r = 0.332、0.329，P 0.05）。 结论 AR、P-PKB在三阴性乳腺癌的表达具有重要的意义，可以作为预后的重要指标，并有望成为未来治疗三阴性乳腺癌的新靶点。 　　[关键词] 雄激素受体；磷酸化蛋白激酶B；三阴性乳腺癌；表达 　　[中图分类号] R737.9 [文献标识码] A [文章编号] 1673-7210（2016）03（b）-0124-04 　　[Abstract] Objective To investigate the expression and significance of androgen receptor （AR） and phosphorylated protein kinase B （P-PKB） in triple negative breast cancer. Methods From March 2012 to March 2015， in Central Peoples Hospital of Huizhou City， 115 patients with breast cancer were selected， among them， 54 cases were triple negative breast cancer， 61 cases were non-triple negative breast cancer. The expression of AR and P-PKB was detected by immunohistochemistry S-P method. The expression of AR， P-PKB， and AR in triple negative breast cancer and triple negative breast cancer tissues were compared， and the relationship between the expression of P-PKB and the clinicopathological parameters were analyzed. Results AR positive expression rate of triple negative breast cancer was significantly lower than non-triple negative breast cancer （P 0.05）； P-PKB positive expression rate of triple negative breast cancer was significantly higher than non triple negative breast cancer （P 0.05）； AR expression of triple negative breast cancer tissues had a significantly negative correlation with clinical stage and lymph node metastasis（r = -0.295， -0.311， P 0.05）； P-PKB expression of triple negative breast cancer tissues had a significantly positive correlation with clinical stage and lymph node metastasis（r = 0.332， 0.329， P 0.05）. Conclusion AR， P-PKB expression have a great signifi