非洛地平并阿托伐他汀治疗单纯收缩期高血压的临床研究.docVIP

非洛地平并阿托伐他汀治疗单纯收缩期高血压的临床研究 　　[摘要] 目的 探讨非洛地平并阿托伐他汀治疗单纯收缩期高血压的临床疗效。方法 方便选取2014年2月―2015年2月于该院住院的72例单纯收缩期高血压患者抽签随机分为两组。对照组（36例）给予非洛地平缓释片口服，观察组（36例）及在对照组的基础上加用阿托伐他汀钙片口服。比较两组患者治疗前后的收缩压、脉压、高敏C反应蛋白的改善情况来评估两组患者药物治疗的临床疗效。 结果 治疗后观察组患者一氧化氮（78.56±8.43）μmol/L较治疗前及对照组治疗后（52.34±8.25）μmol/L显著较高（P0.05），收缩压[（131.25±8.46）mmHg、脉压（56.82±5.46）mmHg、高敏C反应蛋白（7.48±2.16）mg/L较对治疗前及对照组治疗后（145.28±8.09）mmHg、（67.48±6.13）mmHg、（12.15±2.11）mg/L]显著较低，差异有统计学意义（P0.05）。结论 对于治疗单纯收缩期高血压患者，非洛地平并阿托伐他汀治疗比单独用药能更好地降低患者的收缩期血压和脉压，降低患者的血管炎性水平，提高临床疗效。 　　[关键词] 非洛地平并阿托伐他汀；单纯收缩期高血压；疗效 　　[中图分类号] R544.1 [文献标识码] A [文章编号] 1674-0742（2016）10（b）-0140-03 　　[Abstract] Objective To investigate the clinical effect of felodipine and atorvastatin in the treatment of isolated systolic hypertension. Methods Convenient selection from February 2014 to February 2015 in our hospital Seventy-two patients with isolated systolic hypertension in our hospital were randomized into two groups.The control group （36 cases） was treated with oral felodipine sustained-release tablets while the observation group （36 cases）， on the basis of the control group， was treated with atorvastatin calcium tablets. The improvement of systolic blood pressure， pulse pressure and high-sensitivity C-reactive protein before and after treatment was compared between the two groups to evaluate the curative effect of drug therapy.Results After treatment， the nitric oxide level （78.56±8.43）μmol/L in the observation group was significantly higher than that before treatment and that in control group after treatment（52.34±8.25） μmol/L while systolic blood pressure（131.25±8.46） mmHg， pulse pressure （56.82±5.46） mmHg and high sensitivity C reactive protein（7.48±2.16） mg/L were significantly lower than those before treatment and those in the control groupafter treatment（145.28±8.09） mmHg， （67.48±6.13） mmHg， （12.15±2.11） mg/L （P 0.05）. Conclusion For treatment of patients with isolated systolic hypertension， felodipine combined with atorvastatin is better than single dr