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2017-03-16 发布于天津
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Scene unseen Disrupted neuronal adaptation in melancholia during emotional film viewing.pdf

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Scene unseen Disrupted neuronal adaptation in melancholia during emotional film viewing.pdf

NeuroImage: Clinical 9 (2015) 660–667 Contents lists available at ScienceDirect NeuroImage: Clinical journal homepage: /locate/ynicl Scene unseen: Disrupted neuronal adaptation in melancholia during emotional ?lm viewing Matthew P. Hyetta,b,?, Gordon B. Parkera,d, Christine C. Guob, Andrew Zaleskye, Vinh T. Nguyenb, Tamara Yuena,d, Michael Breakspearb,c aSchool of Psychiatry, University of New South Wales, Black Dog Institute Building, Prince of Wales Hospital, Hospital Road, Randwick, NSW 2031, Australia bQIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia cThe Royal Brisbane and Womens Hospital, Butter?eld Street, Herston, QLD 4006, Australia dBlack Dog Institute, Prince of Wales Hospital, Hospital Road, Randwick, NSW 2031, Australia eMelbourne Neuropsychiatry Centre, Faculty of Medicine, Dentistry and Health Science Melbourne School of Engineering, University of Melbourne, VIC 3010, Australia. article info Article history: Received 16 July 2015 Received in revised form 19 October 2015 Accepted 22 October 2015 Available online 24 October 2015 Keywords: Attention Dynamic causal modelling Film viewing fMRI Interoception Melancholic depression abstract Impairments in attention and concentration are distinctive features of melancholic depression, and may diminish the ability to shift focus away from internal dysphoric states. Disrupted brain networks may underlie the inability to effectively disengage from interoceptive signals in this disorder. This study investigates changes in effective connectivity between cortical systems supporting attention, interoception, and perception in those with melancholic depression when shifting attention from rest to viewing dynamic ?lm stimuli. We hypothesised that those with melancholia would show impaired attentional shifting from rest to emotional ?lm viewing, captured in neuronal states that differed little across conditions. Functional magnetic resonance imaging (fMRI) data were acquired fr