替米沙坦对高血压晨峰的控制疗效观察.docVIP

替米沙坦对高血压晨峰的控制疗效观察 　　摘要：高血压患病率在我国呈增加趋势，当高血压病后期心脑肾等靶器官受损或有合并症时，将严重影响人们的健康和生活，故早期治疗高血压，防止靶器官受损及合并症出现非常重要。目前，常用降压药物可归纳为五大类，各类降压药有不同的适应证、禁忌证，要在保证用药安全的基础上发挥其降压疗效，替米沙坦近年来已广泛应用于心血管内科。本文观察了替米沙坦对高血压晨峰的控制疗效[1]。选取门诊轻到中度高血压病患者50例，服用替米沙坦80 mg，每日清晨于血压晨峰前1 h服用，8 w后观察患者治疗前后的对血压的晨峰的控制情况，再次进行动态血压监测。结果 替米沙坦具有明显的控制血压晨峰的疗效，有效率达82%，减少患者发生心脑血管事件。 　　关键词：血压晨峰；替米沙坦；心脑血管事件 　　Abstract：Prevalence of hypertension in the country showed an increasing trend， while the latter part of the heart， brain and kidney disease， hypertension and other target organ damage or complications， it will seriously affect peoples health and life， so early treatment of hypertension， to prevent target organ damage and complications occur very important. At present， the commonly used antihypertensive drugs can be grouped into five categories， all types of antihypertensive drugs have different indications， contraindications， to play their antihypertensive effect of ensuring drug safety， based on telmisartan has been widely used in recent years cardiology. This observation of telmisartan for hypertension control efficacy morning peak [1]. Methods outpatients with mild to moderate hypertension in 50 patients taking telmisartan 80mg， every morning for 1 hour before taking the morning blood pressure surge， after the concept of control was observed after 8 weeks of blood pressure before and after the morning peak of patients case， again ambulatory blood pressure monitoring. Results telmisartan has significant control of blood pressure morning peak effect， the effective rate of 82% reduction in cardiovascular events in patients. 　　Key words：Morning blood pressure surge； Telmisartan；Cardiovascular and cerebrovascular events 　　高血压病患者波动较大的时段是清晨，未经治疗的高血压患者清晨时段收缩压一般波动在升高15～40 mmHg，甚或升高80 mmHg，凌晨血压急剧上升的现象称为高血压晨峰现象[2]。血压晨峰（Morning Surge）与心脑血管病事件的关系更为密切，并与靶器官损坏程度及心血管并发症显著相关。因此，对于高血压患者，有效控制血压晨峰，延缓清晨血压的上升速度对于降低该时段内心血管事件的危险性是十分重要的。替米沙坦属于特异性血管紧张素 Ⅱ 受体拮抗剂的一种， 具有显著的降压效果。 可有效地改善高血压患者的临床体征及症状。 　　1 资料与方法 　　1.1一般资料 随机选取2015年10月～12月门诊高