ppt课件-国外大学细胞生物学ppt课件-英文3.bioy.pptVIP

Common fatal genetic disease Phenotype: thick, sticky mucus ?respiratory congestion ?breeding ground for infection-causing bacteria ?blocks pancreas function Cystic Fibrosis is caused by mutations in CFTR, an anion channel in the apical surface of epithelial cells of the lung, pancreas, intestine and sweat glands. Mutations lead to disruption of fluid secretion into the lung (sticky mucus that cannot be cleared Early sign of the disease: saltiness of skin because fluid secretion works in conjunction with other ion transporters in epithelial cells. * Cystic Fibrosis W2011 D103 Ce