慢性阻塞性肺疾病患者FENO变化的临床意义及其与FEV1FEV1%相关性研究.docVIP

慢性阻塞性肺疾病患者FENO变化的临床意义及其与FEV1FEV1%相关性研究 　　摘要：目的 探讨慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者急性加重期（acute exacrbations of chronic obstructive pulmonary diseases， AECOPD）和稳定期呼出气一氧化氮（FENO）水平变化的临床意义，及其与FEV1，FEV1%的相关性。方法 纳入81例COPD急性加重期到稳定期为研究组，78例健康者为对照组，行FENO、肺功能检查，记录FENO、FEV1、FEV1%值。结果 ①COPD患者急性加重期组FENO水平高于稳定期组；②COPD稳定期组FENO水平高于对照组；③COPD急性加重期组FENO水平高于稳定期组和对照组（P0.05）；COPD稳定期组患者FENO水平与FEV1、FEV1%均无相关性（P0.05）；急性加重期到稳定期FENO改善值与急性加重期到稳定期FEV1改善值之间存在正相关关系（P0.05），与急性加重期到稳定期FEV1%改善值之间亦存在正相关关系（P0.05）。结论 FENO可能在COPD的发生及发展过程中起到重要作用，也是反映COPD患者急性加重的指标，可以作为临床观察指标。 　　关键词：呼出气一氧化氮、慢性阻塞性肺疾病急性加重、肺功能 　　Abstract：Objective To investigate the effects of chronic obstructive pulmonary disease patients with acute exacerbation and remission breath Methods The clinical significance of the change of nitric oxide levels in 81 cases of COPD exacerbations period and stable period for the group， 78 cases of healthy subjects as control group， each group routine lung function， and FENO check， record FEV1， FEV1 %， FENO value. Results ① COPD patients with acute aggravating period of group FENO level were higher than in plateau group；②COPD plateau group FENO level higher than the control group；③ with COPD and restructuring of FENO levels higher than plateau group and the control group （P 0.05）；Patients with COPD stabilization group FENO level had no correlation with FEV1， FEV1 % （P 0.05）；Acute exacerbation period to stabilization FENO improve value with acute aggravating period to stability improved FEV1 value between positive correlation （P 0.05）， with acute aggravating period to improve stability FEV1 % value also exists between the positive correlation （P 0.05）. Conclusion FENO may occur in the COPD and play an important role in the process of development， is probably reflect the index of acute exacerbation of COPD patients. 　　Key words：Breath nitric oxide；Chronic obstructive pulmonary diseases acute exacerbation；Lung function 　　FENO测定是一种评估气道炎症的简单、无创、易行的方法[1，2]，目前国内外已将其广泛应用于支气管哮喘患者的诊断、