从基因组学到蛋白质组学幻灯片.pptxVIP

Genomics is big, Proteomics is enormous The Human Genome is encoded by 23 chromosome pairs These encode ~20,300 different genes c.2001 DNA is composed of 4 chemical bases (nucleic acids) A, G, C, T DNA double helix The “simple” chemistry of DNA has industrialised genomics Caterpillar Butterfly Genome vs. Proteome Proteins are molecular machines of many shapes and sizes Proteins are composed of up to 20 amino acids - Different physical and chemical properties Proteins can fold to form unique structures to provide cellular specificity Large dynamic range of cellular protein levels 106 20,300 pr