奶牛产后感染性子宫疾病对子宫和卵巢的影响研究进展.PDFVIP

微生物学通报 Mar. 20, 2017, 44(3): 710?715 Microbiology China /wswxtbcn tongbao@ DOI: 10.13344/j.microbiol.china.160198 Foundation item: Key Technologies RD Program of China (No. 2011BAD19B02) *Corresponding author: Tel: 86-25 E-mail: suqinhang69@ Received: March 07, 2016; Accepted: May 09, 2016; Published online (): May 24, 2016 基金项目：国家科技支撑计划项目(No. 2011BAD19B02) *通讯作者：Tel：86-25E-mail：suqinhang69@ 收稿日期：2016-03-07；接受日期：2016-05-09；优先数字出版日期()：2016-05-24 专论与综述 奶牛产后感染性子宫疾病对子宫和卵巢的影响研究进展 杨黎明 周亲 呼伦 姚望 杭苏琴* 朱伟云 (南京农业大学消化道微生物实验室 江苏 南京 210095) 摘 要：微生物入侵是引起奶牛产后子宫疾病的主要因素，产后子宫能检出丰富的微生物种群， 主要包括公认的致病菌如大肠杆菌、隐秘脓杆菌、坏死梭杆菌等，机会病原菌如产气荚膜梭菌、 肺炎克雷伯菌、微球菌等和潜在致病菌如消化链球菌、金黄色葡萄球菌等。近年来，运用分子微 生态技术发现子宫中的微生物属于变形菌门、梭杆菌门、厚壁菌门、拟杆菌门和软壁菌门 5个已 知的门和一类未被培养的种群，其中拟杆菌属、梭菌属等种群与子宫疾病密切相关。细菌侵入子 宫后，以大肠杆菌为代表的革兰氏阴性菌和以化脓隐秘杆菌为代表的革兰氏阳性菌可被子宫内膜 细胞上的 Toll 样受体识别引起炎症反应，改变子宫前列腺素分泌类型，影响卵泡发育、黄体大 小，降低血清中雌激素和孕激素浓度，造成奶牛不发情、不排卵，导致产犊间隔延长、产奶量和 产犊数量下降，严重影响奶业经济效益。本文从产后奶牛子宫内主要病原菌的种类及其与子宫健 康状态的关系、子宫内膜对病原菌的识别与先天免疫、子宫疾病对子宫和卵巢功能的影响等方面 对国内外研究进展进行了综述。 关键词：奶牛，产后，子宫疾病，微生物，免疫，卵巢 Advances of the effects of infectious uterine disease on uterus and ovary in postpartum dairy cow YANG Li-Ming ZHOU Qin HU Lun YAO Wang HANG Su-Qin* ZHU Wei-Yun (Laboratory of Gastrointestinal Microbiology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China) Abstract: Infectious uterine diseases are mainly caused by bacteria invasion following parturition in dairy cows. A wide range of bacteria population were revealed in the postpartum uterus of cattle, including recognized uterine pathogens such as Escherichia coli, Arcanobacterium pyogenes, Fusobacterium necrophorum; potential pathogens such as Clostridium perfringens, Klebsiella pneumoniae, Micro Streptococcus; opportunist pathogens such as Peptostreptococcus, Staphylococcus aureus. Recently, phyla of Proteobacteria, Fusobacteria, Firmicutes, Bacteroidetes, Tenericutes and a group of uncultured bacteria were observed in