容量控制对腹膜透析患者微炎症及左室肥厚的影响.pdfVIP

医学临床研究 2007 年 7 月第 24 卷第 7 期 J Clin Res , Jul. 2007 , Vol 24 , NQ7 容量控制对腹膜透析患者微炎症及左室肥厚的影晌 李涌泉张欣洲黄旋珠王丽莹李蜻 (广东省深圳市人民医院肾内科，广东 深圳 518020) [摘要]【目的】探讨严格容量控制对腹膜透析患者微炎症及左室肥厚的影响。 E方法)41 例治疗 6 个月 以上的 CAPD 患者，在专业人员的指导下限制水盐摄入、调整透析处方进行严格的容量控制。比较试验前后 患者容量状态、血清 CRP、血压水平及左心室质量指数的变化。 E结果】本组患者试验前 42.2.%的患者存在容 量超负荷，容量负荷与患者血清 CRP 水平显著相关，试验开始一周内患者总水分清除量与患者血清 CRP 水 平显著正相关。试验结束时患者水肿较前消退，血压良好控制，血清 CRP 水平及左心室质量指数较前显著下 降。 E结论】严格的容量控制能使 CAPD 患者血压控制更为理想、左室肥辱逆转、微炎症减轻。 [关键词] 腹膜透析; 炎症; 肥大，左心室 Effect of Strict Volume Control on Microinflammation and Left Ventricular Hypertroppy in CAPD Patients LI Yong-quan , ZHANG Xin-zhou , HUANG Xuan-zhu ,et al ( ~ρartment of Nephrology , The Shenzhen Peoples Hospital , Guangdong 518020 ,Oúna ) [Abstract](Objective)To explore the effect of strict volume control on microinflammation and left ventric- ular hypertroppy in CAPD Patients. (Methods)Forty one patients treated for more than 6 months were en rolled. Patients were supervised by specialist to restrict salt and water intake , to adjust PD prescription in order to control volume strictly. The volume state , serum CRP level , blood pressure and left ventricular mass index were compared between the beginning of the study and the end of the follow-up period(6 months)[ResultsAt the beginning of the study , 42. 2.% patients of the group were volume-overloaded. Volume load was associated with serum CRP level. In the first week of the study , total volume removal(PD ultrafiltration+urine volume) was positively related to serum CRP level. At the end of the study ,blood pressure was well controlled. Blood pressure , serum CRP level and left ventricular mass index at the end of the study were decreased markedly compared to those at the beginning of the study . (Conclusion)Strict volume control can attain well blood pres- sure control , left ventricular hypertrophy regression and microinflammation recovery. [Key words] peritoneal dialysis; inflammation; hypertrophy, left ventricular [中图分类号] R459.5 [文献标识码