Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodelling.pdf

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2017-04-09 发布于江苏
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Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodelling.pdf

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Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodelling

Review Article Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodelling ? Lei-Guo Ming 1 , Ke-Ming Chen 1 , and Cory J Xian 2 1 Institute of Orthopaedics, Lanzhou General Hospital, Lanzhou Command of PLA, Lanzhou 730050, People’s Republic of China; 2 Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5001, Australia Correspondence: Ke-Ming Chen (PhD) Institute of Orthopaedics, Lanzhou General Hospital, Lanzhou Command of CPLA, Lanzhou 730050, PR China Phone: +86 0931 8994327; Fax: +86 0931 8994950; Email: chkeming@ Running title: Genistein and icariin regulating bone remodelling ?This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as an “Accepted Article,” doi: 10.1002/jcp.24158 Received 01 April 2012; Revised 07 June 2012; Accepted 02 July 2012 Journal of Cellular Physiology ? 2012 Wiley Periodicals, Inc. DOI 10.1002/jcp.24158 Abstract Increasingly natural products particularly flavonoids are being explored for their therapeutic potentials in reducing bone loss and maintaining bone health. This article has reviewed previous studies on the two better known flavonoids, genistein and icariin, their structures, functions, action mechanisms, relative potency, and potential application in regulating bone remodeling and preventing bone loss. Genistein, an isoflavone abundant in soy, has dual functions on bone cells, able to inhibit bone resorption activity of osteoclasts and stimulate osteogenic differentiation and maturation of bone marrow stromal progenitor cells (BMSCs) and osteoblasts. Genistein is an estrogen receptor (ER)-selective binding phytoestrogen, with a greater affinity to ER . Genistein inhibits