Polycaprolactone.ppt

 Polycaprolactone (PCL) Huimin Huang 2015.1.26 Outline Introduction of PCL Synthesis and biodegradation of PCL Application of PCL as biomaterials Conclusion Introduction of PCL a low melting point of around 60°C and a glass transition temperature of about ?60 °C. biodegradability(The -coo, ester base structure of molecular in nature is easily broken down by microorganisms or enzymes to produce to CO2 and H2O) good biocompatibility low molecular weight colorless crystalline solid Introduction of PCL Polycaprolactone(PCL) is a semicrystalline polymer. It is a chemical synthesis and biodegradable polymer material. For its structure, its repeat unit has five nonpolar methylene - CH2 and a polar ester base -coo. [CH2 - (CH2) 4 - coo] n. Synthesis of PCL PCL is prepared by ring opening polymerization of ε-caprolactone using a catalyst such as stannous octoate. Biodegradation of PCL Firmicutes and proteobacteria can degrade PCL. Penicillium sp. strain 26-1 can degrade high density PCL,though not as quickly as thermotolerant Aspergillus sp. strain ST-01. Species of clostridium can degrade PCL under anaerobic conditions. Applications It can be completely biodegradable plastic surgical sutures. Applications A variety of drugs have been encapsulated within PCL beads for controlled release and targeted drug delivery. Applications It has been used as the hydrophobic block of amphiphilic synthetic block copolymers used to form the vesicle membrane of polymersomes. Applications It can be long term implantable devices. Process: heat this kind of polymer in the saltwater until it becomes flexible form the shape of the missing bones accurately Bone bubble into the body bone cells replace bone bubble polymer will eventually be absorbed out to the body a low melting point of around 60°C and a glass transition temperature of about ?60 °C. It has good compatibility with biological