胆固醇代谢课件1.pptVIP

胆固醇代谢平衡调控;提纲;;一、胆固醇的生物学功能;哺乳动物细胞模式图;膜上的微结构域;Cholesterol and cholesterol derivatives ;脂肪酸、糖等提供能量（ATP） 胆固醇并不提供能量;二、胆固醇相关疾病;Cholesterol is the major cause of atherosclerosis;;蒙娜丽莎患有高胆固醇？;胆结石;From IMS Health, MIDAS ;三、胆固醇的生物合成;Cholesterol is not required in the diet;Cholesterol is made from acetyl-CoA in four stages;Stage 1;Two molecules of acetate-CoA condense forming acetoacetyl-CoA. Acetoacetyl-CoA condenses with acetyl-CoA to yield b-hydroxy-b-methylglutaryl-CoA (HMG-CoA);The final step the reduction of HMG-CoA to mevalonate, catalyzed by HMG-CoA reductase.;Stage 2;Stage 3;Cyclization of squa