ResveratrolImprovesMitochondrial翻译.doc

Diminished mitochondrial oxidative phosphorylation and 减少线粒体氧化磷酸化 aerobic capacity are associated with reduced longevity 和供氧能力与减少寿命相关。 We tested whether resveratrol(RSV), which is known to extend lifespan,impacts mitochondrial function and metabolic homeostasis.我们测试res是否有众所周知的使人长寿，影响线粒体的功能和代谢的稳态。 Treatment of mice with RSV significantly increased their aerobic capacity（有氧能力）, as evidenced by their increased running time and consumption of oxygen in muscle fibers。治疗 加入res的小鼠显著增加他们的有氧能力(有氧能力),正如他们在肌肉纤维增加运行时间和消耗的氧气。 RSV’s effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in PGC-1a acetylation and an increase in PGC-1a activity.res的作用与氧化磷酸化和线粒体生物学的一个感应基因有关。而且很大程度上解释了白藜芦醇介导的PGC-1a乙酰化的下降和PGC-1a活性的上升。 This mechanism is consistent with RSV being a known activator of the protein deacetylase, SIRT1, and by the lack of effect of RSV in SIRT1-/- MEFs.这一机制与白藜芦醇作为SIRT1（去乙酰化酶，蛋白质）的激活剂是相符的，在敲出了sirt1的小鼠成纤维cell中res失去了作用。 Importantly, RSV treatment protected mice against diet-induced-obesity and insulin resistance. 更重要的是res治疗可防止老鼠产生食物诱导的肥胖和胰岛素的抗药性。 These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis.res的药理学作用在芬兰的项目中联合了3个sirt1 snps，和能量平衡，影响了sirt1作为能量和代谢平衡的重要调解者。 (SNPs分析(Single Nucleotide Polymorphisms, 单核苷酸多态性) 同样得到了广泛的重视。SNPs是当碱基序列中只有一个碱基被其他碱基置换所造成的单个碱基所呈现出的变异多样性的情况) INTRODUCTION Mitochondria are the principal energy sources of the cell that convert nutrients into energy through cellular respiration(Wallace, 2005).线粒体是细胞内主要的能量来源，通过细胞内呼吸作用讲营养素转化成能量。 Compromised mitochondrial function has been linked to numerous diseases, including those of the metabolic and cardiovascular systems (Petersenet al., 2003).线粒体的受损一直与很多疾病有关联，包括代谢和心血管疾病。 The genetic basis of such a tight link in the rat was illustrated by the cosegregation of ca