Chapter 1 Pharmaceuticals, biologics and biopharmaceuticals.pptVIP

Chapter 1Pharmaceuticals, biologics and biopharmaceuticals;1.INTRODUCTION TO PHARMACEUTICAL PRODUCTS;Biopharmaceutics;2.BIOPHARMACEUTICALS AND PHARMACEUTICAL BIOTECHNOLOGY; Biotechnology medicine ‘biotechnology medicine’ is defined as ‘any pharmaceutical product used for a therapeutic or in vivo diagnostic purpose, which is produced in full or in part by either traditional or modern biotechnological means’.;;3. HISTORY OF THE PHARMACEUTICAL INDUSTRY;　　　;4 .THE AGE OF BIOPHARMACEUTICALS; Recombinant DNA technology has had a four-fold positive impact upon the production ofpharmaceutically important proteins: It overcomes the problem of source availability. It overcomes problems of product safety. It provides an alternative to direct extraction from inappropriate/dangerous source material. It facilitates the generation of engineered therapeutic proteins displaying some clinical advantage over the native protein product. ;4.BIOPHARMACEUTICALS: CURRENT STATUS AND FUTURE PROSPECTS;;5.TRADITIONAL PHARMACEUTICALS OF BIOLOGICAL ORIGIN;Pharmaceuticals of animal origin;2.看护培养法;3.微室培养法;4.条件培养法; 5.悬浮培养法;　　（五）悬浮细胞培养的同步化方法;　　（六）细胞的保存;（七）植物细胞的生物反应器的大规模培养; 2.气升式反应器培养; 3.鼓泡式反应器培养;4.固定化细胞生物反应器培养;填充床反应器：将细胞固定在胶粒、金属或泡沫颗粒或连续的多孔网中，也可以位于支撑物表面，细胞固定不动，通过流动的培养液实现混合和传质。 优点：单位体积容量大。 缺点：混合效率低、传质效率低；固定床颗粒或支持物碎片会阻塞液体流动；用于固定的细胞材料在高压下容易变形，导致固定床的阻塞。; 膜生物反应器：采用具有一定孔径和选择透性的膜固定植物细胞，将培养液和细胞在物体上隔离的一种反应器。 中空纤维反应器：如图所示。 优点：细胞培养和产物分离可同时进行，利于连续化生产。 缺点：清洗反应器困难，只适合于植物细胞胞外代谢物的生产。 ;（八）药用植物草麻黄细胞的大规模培养;2.工艺过程;　　（九）任务驱动下的理论;2.影响细胞生长和次生代谢产物合成的因素;3.培养基的组成和分类; （5）常用培养基配??及其特点;THANK YOU！