(zhaorenyi)血浆纤维蛋白原在冠心病诊断中的临床意义.doc

血浆纤维蛋白原在冠心病诊断中的临床意义 作 者 (单 位) 摘 要：目的 探讨血浆纤维蛋白原在冠心病诊断中的临床意义。方法 选取128例临床资料齐全的冠脉造影患者作为临床研究对象，根据冠状动脉造影结果分为冠心病组与正常组；冠心病组中根据临床分型分为AMI(31例)、UAP(42例)\、SAP(23例)三组，根据冠脉病变程度分为轻度病变组(28例)、中度病变组(30例)、重度病变组(38例)。结果 冠心病组患者的Fib水平为493.75±187.34mg/dL，显著高于对照组的Fib水平为303.4±56.38 mg/dL (P0.01)；AMI组与SAP组的Fib含量与阳性率均明显高于SAP组和对照组，且AMI组的Fib含量明显高于UAP组(P0.05)；不同程度病变组的Fib含量与Fib阳性检出率均明显高于对照组，且重度病变组的Fib含量明显高于轻、中度病变组，而重度与中度病变组的Fib阳性率明显高于轻度病变组。结论 Fib的检测对判断冠脉病变严重程度，尤其重度冠脉病变有较好的临床指导意义。 关键词：血浆纤维蛋白原；冠心病；诊断 The clinical significance of plasma fibrinogen in the diagnosis of coronary heart disease Abstract: Objective To discuss the clinical significance of plasma fibrinogen in the diagnosis of coronary heart disease. Methods 128 coronary angiography patients with complete clinical data were studied. According to the results of coronary angiography, patients were divided into coronary heart disease group and normal group. The coronary heart disease group was divided into AMI(31cases), UAP(42cases) and SAP(23cases) group according to clinical types. According to the degree of coronary artery disease, the coronary heart disease group was divided into mild lesions (28 cases), moderate lesions (30cases) and severe lesions (38cases). Results The Fib level of coronary heart disease group is 493.75±187.34 mg/dL, distinctly higher than the one of normal group (P0.01). Fib amount and positive percentage of AMI and SAP group are both higher than the one of SAP and normal group, and the Fib amount of AMI group is distinctly higher than the one of UAP group. Fib level and positive ratio of different degree group are both higher than the one of normal group. The Fib of severe group is higher than the mild and moderate group and the positive ratio of severe and mild group is higher than the one of mild group. Conclusion Fib detection had better clinical guidance for the determination of the coronary artery disease degree, especially for severe coronary artery disease. Keywords: plasma fibrinogen; coronary heart disea