抗糖尿病药物合成进展.docxVIP

抗糖尿病药物合成进展 摘要：糖尿病是一种病因复杂的慢性疾病，严重威胁着人体健康，其患病率呈逐年上升趋势，治疗糖尿病已成为全球性的重大公共卫生问题。研究者不断开发研制新型、有效、安全的治疗药物，现研究的抗糖尿病化合物主要分为化学合成类药物包括胰岛素增敏剂、胰岛素促分泌素、肠促胰岛素、钠-葡萄糖共转运蛋白2抑制剂、α-葡萄糖苷酶抑制剂、胰岛淀粉样多肽类似物，以及一些对天然活性物质改性的药物。本文就目前开发的抗糖尿病化合物进行了分类，简单阐述了其作用机制与合成方法，并提出今后抗糖尿病药物研究发展趋势。 关键词：糖尿病；降糖药；合成；机理 Synthesis and Advances in Anti-diabetes Drugs Abstract:As a chronic disease, diabetes threatens human health seriously. The prevalence of diabetes is increasing annually, and the treatment of diabetes has become a major global public health problem.Researchers develop new, effective and safe therapeutic drugs constantly, the synthetic antidiabetic drugs includes insulin sensitizers, insulin secretagogues, incretins,sodium - glucose co-transporter 2 inhibitors, á-glucosidase inhibitors, amylin analogs and some of the natural active substances modified drugs. In this paper, the current study of anti-diabetic compounds were classified, and briefly described its mechanism of action and synthesis methods, put forward the development trend of the future anti-diabetic drug research . Keywords: diabetes; hypoglycemic drugs; syntheses；mechanism 1.引言 糖尿病是一种内分泌代谢性型疾病，由体内胰岛素绝对或相对不足所致。近年来，糖尿病的患病率逐年增加，2015年全球患糖尿病的人口约为4.15亿，预计2040年将会增至6.42亿 ADDIN EN.CITE EndNoteCiteAuthor项坤三/AuthorYear2004/YearRecNum1/RecNumDisplayTextstyle face=superscript[1]/style/DisplayTextrecordrec-number1/rec-numberforeign-keyskey app=EN db-id=asav0w0straedsed2s8vp9ssvdt9ztwdftaz timestamp=14807249671/key/foreign-keysref-type name=Journal Article17/ref-typecontributorsauthorsauthor项坤三/authorauthor纪立农/authorauthor向红丁/authorauthor杨文英/authorauthor贾伟平/authorauthor钱荣立/authorauthor翁建平/author/authors/contributorstitlestitle中华医学会糖尿病学分会关于代谢综合征的建议/titlesecondary-title中华糖尿病杂志/secondary-title/titlesperiodicalfull-title中华糖尿病杂志/full-title/periodicalpages156-161/pagesvolume12/volumenumber3/numberdatesyear2004/year/datesurls/urls/record/Cite/EndNote[ HYPERLINK \l _ENREF_1 \o 项坤三, 2004 #1 1]。如果不能积极有效地对糖尿病进行治疗，极易引发诸多威胁糖尿病病人的生命安全的并发症，因此，研制出安全、高效抗糖尿病药物来维持