《Tigecycline in the intensive care unit what has clinical experience taught us》.pptVIP

Tigecycline in the intensive care unit: what has clinical experience taught us?;新春愉快，恭喜发财;Striking the balance between;The Goals of Empiric Antibacterial Therapy;;;Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock;OPTAMA: Northern China(Shenyang, Beijing, Tianjin and Jinan);;Tigecycline;Tigecycline clinical trials;Tigecycline vs imipenem-cilastatin:  complicated intra-abdominal infection clinical cure rates;;Tigecycline vs vancomycin-aztreonam: complicated skin and soft tissue infection clinical cure rates;;Tigecycline in the ICU;;Baseline characteristics;Risk factors;Patient outcome;Duration of ICU stay prior to tigecycline;Reasons for use;Combination tygacil plus…;Tigecycline: indications and aetiology;Tigecycline: clinical experience;Adverse events in critically ill patients;Adverse events;;Pathophysiology of MODS: Effects on Drug Vd and CL;Vd’ changing in ICU sepsis patient;Effect of SIRS on Volume of distribution; Clinical Efficacy of Two High Tigecycline Dosage Regimens Versus Imipenem- Cilastatin in Hospital-Acquired Pneumonia: Results of a Randomized Phase II Clinical Trial (2000 Study) Hassan Gandjini, Paul McGovern, M.D. , Jean Li Yan , Nataile Dartois, M.D. AAC, published online ahead of print on 28 January 2013 ;2000 HAP Study Design;2000 HAP Study Design;When dosage raised, Efficacy Improves;Severe pts benefit most from dosage escalation;Safety Profiles Remain Good;Conclusions ;Summary ;Advantages for using tigecycline in intensive care; jrello@crips.es