-blocker propranolol in rats after traumatic brain injury in IL1 and IL1Ra of.docVIP

 PAGE \* MERGEFORMAT 14 -blocker propranolol in rats after traumatic brain injury in IL1 and IL1Ra of Study: Rich Baixiang Jun TANG Zhao-Hui Qiu Wei [Abstract] Objective To investigate the -blocker (propranolol on brain tissue after traumatic brain injury in interleukin 1 (IL 1 and interleukin-1 receptor antagonist (IL 1Ra. Methods large selection SD 72 rats were randomly divided into control group (36 treatment group (36. Feeney method using the modified rat model of right parietal brain injury were given saline, intraperitoneal injection of propranolol (40mg/kg. 6,24,72 hours after injury in each group at 3 time points, take the right parietal lobe injury in the brain tissue, hematoxylin eosin staining (HE staining to observe the pathological changes, immunohistochemistry and immunoblotting (Western blotting to detect which IL 1 and IL 1Ra expression. Results In the control group: 6 hours after injury, neuronal degeneration and necrosis could be seen, and a large number of IL 1 expression peaked at 24 hours, IL 1Ra expression of a very small and gradually increased. Treatment group: significantly reduced neuronal necrosis, IL 1 expression decreased, while IL 1Ra 6 hours that are clearly expressed and continues to 72 hours, and IL 1/IL 1Ra ratio lower than the control group. the two groups, the difference was significance (P lt;0.05). Conclusion -blockers can significantly reduce brain injury District IL 1 expression, increased expression of IL 1Ra, may reduce the inflammatory injury after traumatic brain injury has a role. [Keywords:] propranolol in rats with brain interleukin-1 IL-1Ra Studies have shown that interleukin 1 (IL 1 as a proinflammatory cytokine involved in inflammatory response after traumatic brain injury [1]. Woiciechowsky [2] study confirmed that -blockers can block IL 1-induced central nervous system inflammation. interleukin-1 receptor antagonist (IL 1Ra is a naturally occurring brain tissue, can reduce inflammatory injury IL 1