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-defensin in the distribution of chronic tonsillitis and functional organization
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-defensin in the distribution of chronic tonsillitis and functional organization
[Keywords:] defensin; tonsillitis
-defensin is a recently discovered class of small molecules with positively charged peptides with anti-bacterial, anti-virus, anti-fungal and anti-tumor activity, especially with antibacterial activity. Chronic tonsillitis is a bacterial infection, pathogenic microorganisms tonsil infection and immune status in itself is the initiating factor of tonsillitis. In this study, -defensin in the tonsil tissue distribution and function are reviewed in order to understand both the -defensin-occurrence of chronic tonsillitis, the status of development and research status of research.
1, the basic situation of defensins
Defensin (defensin is a group of cysteine-rich peptides, the molecular weight range of 3.5 ~ 4.5 kD, cysteine formed by a 3 to 4 on the stability of the disulfide bonds. Exist in different species of animal phagocytes , small intestine Paneth (Paneth cells and epithelial cells and plants, 30 kinds have been found so far defensin, including the four sub-families, namely, plant defensins, insect defensins, @ defensins and defensins. So far, 6 kinds of people have been found @ defensin (HNP-1 ~ 4, HD-5, HD-6 and 6 of human defensins (HBD-1 ~ 6, @ defensin mainly by neutrophils and intestinal mammalian Paneth cells, also found in females of reproductive epithelium. where defensins are mainly distributed in vertebrate skin, mucous membranes and other epithelial tissue to form outside the body to resist chemical attack of the first barrier, is the largest family of endogenous peptide antibiotics. defensins not only in the cell membrane to form pores and channels, leading to irreversible cell death to kill bacteria, viruses and fungi and other pathogens, but also has a neutrophil chemotactic, phagocytic cells conditioning. thus the specific and nonspecific biological play an important role in immunity.
-def
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