0DNA topoisomerase and telomerase and the relationship between multidrug resistance in leukemia.docVIP

 PAGE \* MERGEFORMAT 26 0DNA topoisomerase and telomerase and the relationship between multidrug resistance in leukemia Abstract tumor cell resistance to cancer therapy for many the key to success, but also the blood of the important reasons for failure of cancer chemotherapy, at present people from a different perspective and level of the mechanism of resistance to reverse drug resistance in drug research and the corresponding body internal and external experiments to study pointed out that the multi-drug resistance is the result of a variety of factors. In recent years, not a typical drug resistance of leukemia increased attention has been paid, this article from the DNA topoisomerase, and the relationship between telomerase and the leukemia drug resistance proceeding described multi-drug resistance in leukemia cells, anti-apoptosis mechanism, Zhi for the reversal of drug resistance of leukemia and development of effective lay the theoretical basis for reversal agents. Keywords: DNA topoisomerase multidrug resistance in leukemia, telomerase DNA Topoisomerase and Telomerase Activity with Relation to Multi  Drug Resistance in Leukemia - Review Abstract The appearance of multi  drug resistance becomes a key to treat many malignanccies, and also is an important factor in the failure of chemotherapy. Presently, the studies on multi  drug resistance mechanism, reversor and associated exterior experiments in vivo and in vitro from different points of view and levels show that multi  drug resistance is the result of common action in many factors. In recent years non  representative mechanism of multi  drug resistance becomes more and more significant. This review aims at establishing rationale basis for reversing multi  drug resistance of leukemia and finding effective reversors by expounding the mechanism of apoptosis in drug resistance of leukemia with relation to DNA topoisomerase and telomerase activity. Keywords: DNA