1,6 diphosphate preconditioning in rabbits with acute renal ischemia-reperfusion injury in rats.docVIP

 PAGE \* MERGEFORMAT 9 1,6 diphosphate preconditioning in rabbits with acute renal ischemia-reperfusion injury in rats Of: Liu Xinghai Li LIU Zheng Qianjing buy Chinese E Wen Zhigang Yi [Abstract] Objective: To observe the 1,6-diphosphate (FDP) pretreatment on acute renal ischemia-reperfusion injury in rats. Methods: 27 New Zealand white rabbits were randomly divided into sham operation group (S group), lack of blood reperfusion group (I group), 1,6-diphosphate pretreatment group (F group). with right renal artery and vein occlusion of the left kidney removed 60min 180min reperfusion induced renal injury model, continuous 4d given preoperative FDP. 180min after reperfusion, respectively, serum creatinine (Scr), blood urea nitrogen (BUN), kidney tissue malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity, pathologic changes of renal tissue and renal tubular points, and 3 groups were compared. Results: Compared with the S, I set the Scr, BUN, MDA levels were significantly higher (P lt;0.05), SOD activity decreased significantly (P lt;0.01). F group, Scr, BUN, MDA levels were significantly lower than those of I (P lt;0.01 or P lt;0.05), while SOD activity was significantly enhanced (P lt;0.01). F mild renal pathological changes in the I group. CONCLUSION: FDP pretreatment on rabbit Renal ischemia-reperfusion injury has a protective effect, the protective mechanisms may be related to increased SOD activity and remove excess oxygen free radicals and reduce the MDA formation related. [Keywords:] 1,6-diphosphate; pretreatment; kidney; ischemia-reperfusion injury Renal ischemia-reperfusion (Ischemia / Reperfusion, I / R) injury caused by acute renal failure in clinical high morbidity and mortality. Therefore, how to reduce or prevent renal ischemia-reperfusion injury has been a clinical and experimental research focused .1,6 diphosphate (FDP) as high energy glycolytic intermediate metabolites, in recent years found their heart, brain, small