21 d simulated weightlessness on the rabbit brain water content and morphology of.docVIP

 PAGE \* MERGEFORMAT 2 21 d simulated weightlessness on the rabbit brain water content and morphology of Authors: Jie Geng, Xi-Qing Sun, Hui-Pin Sun, Xin-Sheng Cao [Keywords:] Brain edema Effects of 21d HDTinduced simulated weightlessness on cerebral water content and cerebral tissue in rabbits [Abstract] AIM: To observe the effects of simulated weightlessness induced by 21 d, -20 ° headdown tilt (HDT) on the cerebral water content and histological changes in rabbits. METHODS: The weightlessness simulation model was set up by use of HDT. Twentyfour healthy male rabbits were randomly divided into three groups of 8 each: 21 d weightlessness group, 45 ° HUT 2 h per day group (countermeasure), control group. After 21 d simulated weightlessness, the cerebral water content and histological examination were observed. RESULTS: ① There were no significant differences in the cerebral water content between the control, weightlessness and countermeasure groups. ② Under light microscope, no red blood cell effusion, blood vessel or cell spaces distention were found among all the three groups. No vacuoles or cellular swelling was found in brain tissues. CONCLUSION: The 21 d weightlessness simulation does not cause brain edema or histological changes in rabbits. [Keywords] weightlessness simulation; brain edema; cerebral water content; brain tissue; headdown tilt [Abstract] Objective: To observe the 21 d head-down simulated weightlessness on the rabbit brain water content and morphology. Methods: The buck low -20 ° tilt method of simulated weightlessness. 24 healthy male rabbits were randomly divided into control group, 21 d simulated weightlessness group and 2 h day 45 ° head-up tilt against the group, n = 8. experiment 21 d after the observation of brain water content and histological changes. Results: ① the control group, simulated loss of reorganization, against the group brain water content was no significant difference (P