5 - hydroxytryptamine on the impact of megakaryocyte hematopoietic.docVIP

 PAGE \* MERGEFORMAT 32 5 - hydroxytryptamine on the impact of megakaryocyte hematopoietic Abstract 5 - hydroxytryptamine (5-HT) is a cell growth factor, mainly integrated into the cell surface 5-HT1 receptor ,5-HT2 receptors, through the Ras, MAPK pathway to promote a variety of cell proliferation. Megakaryocyte hematopoiesis in the early ,5-HT through 5-HT2B receptor for hematopoietic stem cells and megakaryocyte progenitor cell proliferation and differentiation of the specific mechanisms are not yet very clear; in the late megakaryocyte hematopoietic ,5-HT and 5-HT2A receptor with the promotion of nitric oxide synthesis, may be the release of platelets have a certain impact. In addition ,5-HT can be against platelet α-granule contents of platelet-reactive protein -1 (TPS-1) caused by megakaryocyte apoptosis, together the contents of another platelet-derived growth factor (PDGF) induced proliferation of megakaryocytes, it platelet 5-HT may be more important in feedback regulation of substances. In this paper, 5HT receptor, 5HT is a cell growth factor, 5HT promote cell proliferation of channels and 5HT on megakaryocyte progenitor cells are reviewed. Keywords: 5 - HT Effect of 5-Hydroxtryptamine on Megakaryocytopoiesis - Review Abstract 5-hydroxtryptamine (5-HT, serotonin) has been recognized not only as a neurotransmitter and vasoactive agent, but also as a growth factor.5-HT mainly binds to 5-HT2 receptors or 5-HT1 receptors on cell surface to stimulate cell proliferation through Ras or MAPK pathway in many cell types.It has been reported that 5-HT stimulates megakaryocytopoiesis via 5-HT receptors.The possible mechanism of 5-HT on the proliferation and differentiation of megakaryocytes (MK) has been discussed in this review article.In early stage of megakaryocytopoiesis ,5-HT may bind to 5-HT2B receptor on megakaryocytes, and promotes their proliferation and differentiation.In the late stage ,5-HT may involve in the platelet r