6% OH-based starch 130-0.4 has been pre-filled bypass heart surgery in children with liver and kidney function and blood coagulation.docVIP

 PAGE \* MERGEFORMAT 9 6% OH-based starch 130/0.4 has been pre-filled bypass heart surgery in children with liver and kidney function and blood coagulation [Abstract] Objective To investigate the 6% hydroxyethyl starch 130/0.4 (6% HES 130/0.4) CPB (cardiopulmonary bypass, CPB) heart surgery in children with pre-charge of the liver and kidney function and blood coagulation function. Methods 40 cases of open heart surgery OK CPB in children, sex not limited to, age ≤ 6 years old, were randomly divided into experimental group (6% HES 130/0.4 pre-filling, n = 20) and the control group (plasma pre-filling, n = 20). , Respectively, the day before surgery (T0) and immediately the end of surgery (T1) to take in children with 2 ml venous blood were sent into two test tubes in children with biological and chemical detection chamber alanine aminotransferase (ALT), total bilirubin Su (TBIL), urea (UREA), creatinine (CREA), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fbg). Results Compared with control group, experimental group ALT, TBIL, CREA decreased significantly (P amp;lt;0.05), PT, APTT and Fbg decreased significantly prolonged (P amp;lt;0.05). Conclusions Pre-CPB charge 6% HES 130/0.4 on renal function of children with cardiac surgery without injury, but has a protective effect on the coagulation impact, but no clinical significant bleeding. [Keywords:] OH has been the base starch; liver and kidney function; coagulation; cardiopulmonary bypass; infant and young child Abstract: OBJECTIVE To evaluate the effect of hydroxyethyl starch 130/0.4 (HES) used as priming solution for cardiopulmonary bypass CPB) on hepatic-renal function and coagulation in infants undergoing cardiac surgery. METHODS Forty infants of either sex, aged ≤ 6yr undergoing cardiac surgery with CPB were randomly divided into 2 groups (n = 20 each): HES group and plasma group. Blood samples were taken from the vein at one day before surgery (