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A142 cortical neurons induced apoptosis and the intervention of Tongxinluo
PAGE \* MERGEFORMAT 11
A142 cortical neurons induced apoptosis and the intervention of Tongxinluo
Of: Zhang Zhihui Zhou [Abstract] Objective To study A induced apoptosis of cortical neurons and Tongxinlou intervention. Methods Primary cultured mouse cortical neurons, the A1 42 after treatment, MTT determine neuronal survival, Hoechst33342 staining, flow cytometry test to detect neuronal apoptosis, Western blot the expression of caspase apoptotic protein. Results of neurons treated by A1 42, reduce the number of living cells, chromatin condensation, nuclear fragmentation, staining positive neurons, cells withered death rate increased, caspase 3 expression increased. Tongxinluo can improve the above changes. Conclusion A induced by caspase 3 pathway leading to neuronal apoptosis in neuronal cell death. TXL could inhibit neuronal apoptosis induced by A to protect neurons, which play a role in treatment of AD.
[Keywords:] A amyloid protein, TXL, neuronal apoptosis, caspase 3, apoptosis-related gene
[Abstract] Objective To study the mechanism of amyloid (A) on neuron apoptosis and the effect of Tongxinluo. Methods The neuron survival, apoptosis of neurons were detected by Hoechst 33 342 staining, the expression pf caspase 3 was determined by Western blot. Results The number of viable cells was decreased and the condensation of chromatin and nuclear fragmentation were shown after A1 42 treatment. The expression of caspase 3 was elevated after treated with Tongxinluo, all the above indexes were improved. Conclusions The mechanism of A1 42 inducing neuron apoptosis is related to its regulation on the expression of apoptosis associated gene and the caspase 3 pathway. Tongxinluo could attenuate the neurotoxic action of A1 42 and improve neuron survival.
[Keywords:] amyloid protein; Tongxinluo; Neuron apoptosis; Caspase 3; Apoptosis associated gene
Alzheimer’s disease (AD) belong to the motherland medicine “stay disease” and “forgetfulness” and other
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