About Qi decoction on platelet activation in patients with coronary heart disease rate of.docVIP

 PAGE \* MERGEFORMAT 10 About Qi decoction on platelet activation in patients with coronary heart disease rate of [Abstract] Objective To observe Qi decoction on platelet activation in patients with coronary heart disease rates. Methods 75 patients with coronary heart disease were randomly divided into control group (35 cases) and treatment group (40 cases), conventional western medicine treatment for the control group the treatment group took Yiqihuoxue Chinese medicine, observed two groups before and after treatment of platelet membrane P selectin (CD62p) and platelet activating glycoprotein Gp Ⅱ b / Ⅲ a (PAC-1) expression. Results Yiqihuoxue Chinese medicine treatment for 2 months , platelet surface-active marker proteins CD62p, PAC-1 expression decreased, with its own control group before treatment and after treatment were significantly different (P lt;0.05). Conclusion Qi decoction on coronary heart disease patients have a good anti- platelet activation. [Keywords:] Yiqihuoxue Chinese medicine, coronary heart disease, platelet activation Common for the elderly with coronary heart disease, atherosclerosis and thrombosis is based on the pathological, and platelet activation and blood coagulation system is the combined effect of thrombus formation. Research shows that patients with coronary heart disease in a high activation state of platelets in general, is thrombosis high-risk patients [1], and P selectin (CD62p) is a platelet activation mark. With coronary disease increased, CD62p activity was significantly increased [2], and platelet-activating glycoprotein Gp Ⅱ b / Ⅲ a (PAC-1) is Early detection of platelet activation and effective means. Yiqihuoxue my experience in the prescription for the party, and coronary heart disease have better clinical efficacy. To investigate the mechanism of its efficacy, this study CD62p, PAC-1 for the detection index, to observe its platelet activation in patients with coronary heart disease-positive rate. 1 Mate