Adenosine A2A receptors- an important molecule regulating immune.docVIP

 PAGE \* MERGEFORMAT 18 Adenosine A2A receptors: an important molecule regulating immune [Abstract] adenosine A2A receptor is currently known of the four adenosine receptors (A1, A2A, A2B, and A3), one was in high expression of immune cells, after activation of the immune cell function by closely involved in regulating the inflammatory response, immune tolerance and other immune regulation. but in different pathological conditions, A2A receptor activation of the immune regulation in a different direction, producing different effects. Therefore, the immunomodulatory effects of different receptors causes and mechanisms of in-depth research to effectively play its protective role, while avoiding damage effects, the clinical disease for the rational use of immunotherapy A2A receptor modulators basis. [Keywords:] adenosine; A2A receptor; immune regulation Abstract: Adenosine A2A receptor is one of the four known adenosine receptors (A1, A2A, A2B and A3), which is highly expressed on the immunocytes.A2A receptors can modulate a lot of immune responses, such as inflammation and immune tolerance, by regulating the functions of immunocytes.But in different pathological conditions, activation of A2A receptors exerts different effects and activities.Accordingly, it is necessary to illustrate the mechanism of the complex immunoregulation role of A2A receptors to educe their beneficial effects while avoiding their deleterious activities, which may lay the foundation for immunological treatment for clinical diseases by regulating A2A receptors. Keywords:: adenosine; A2A receptor; immunoregulation Is the body to maintain immune homeostasis, to fend off an important means of noxious stimulation. Adenosine as an important neurotransmitter and body conditioning, and cell injury in the metabolic disorder will rise sharply, activation of adenosine receptor play a biological effect, participate in immune regulation. Recent studies show that ischemic hypoxia, inflamma