API trace Mannitol Sorbitol.docVIP

 PAGE \* MERGEFORMAT 23 API trace Mannitol Sorbitol Author: Dr WEI Zhen-Lei Deng Liang Hua Luo Ming Abstract At present the production of bulk drugs by chemical synthesis of mannitol method to gradually replace the seaweed extraction method, chemical synthesis of raw materials more or less drug mannitol containing trace amounts of sorbitol. From the production of raw materials and processes described both mannitol sorbitol product contains trace the causes. Keywords: bulk drugs; mannitol; trace; sorbitol 1 Overview Mannitol (D  mannitol) as raw material medicine and preparation of National Cheng Kung University infusion that its role is dehydration diuretic suitable in the treatment of cerebral edema, glaucoma, edema caused by large-scale burns, prevention and treatment of renal failure. Can be used to treat the following diseases: ① cerebral edema caused by inflammation: such as meningococcal meningitis, Japanese encephalitis, tuberculosis, meningitis, etc.; ② cerebral edema caused by cerebrovascular diseases: diseases such as cerebral hemorrhage, hypertensive encephalopathy, etc. ; ③ hypoxic injury in cerebral edema: such as traumatic brain injury, carbon monoxide poisoning, drug or pesticide poisoning; ④ acute glaucoma. If the pharmaceutical excipients can be used as excipients, sweeteners, fillers, etc. can also be done downstream of drug precursors, or intermediates. Mannitol is currently the main source is from kelp extract or chemical synthesis, the two quality indicators according to “Chinese Pharmacopoeia” in the method of detection, there is no difference between levels. But according to the United States, Britain, Europe and other countries in the pharmacopoeia used to detect chemical synthesis will find that the production of mannitol containing trace amounts of sorbitol. Pharmacopoeia of China and Japan on the detection of mannitol content is used by chemical method was determined that the oxidation