Application of cardiac valve replacement 1,6 - diphosphate on myocardial protection of.docVIP

 PAGE \* MERGEFORMAT 13 Application of cardiac valve replacement 1,6 - diphosphate on myocardial protection of Of: Huang Zhiyong, Shangyi Ji, Wang Yi, Ye Xiaoqing, Wu Guiyun [Abstract] Objective 1,6 - diphosphate (FDP) in heart valve replacement surgery on myocardial protection. Methods 60 cases of valve replacement patients were randomly divided into experimental and control group, n = 30. Experiment group before CPB and the intravenous infusion, respectively, from the center by the Myocardial protection was added with FDP 150 mg / kg, Zeyi replaced by normal saline control group. two different points in the perioperative period of cardiac troponin testing of central venous blood I (cTnI), creatine kinase isoenzyme (CKMB), lactate dehydrogenase (LDH), myoglobin (MYO); clinical observation of cardiac auto-resuscitation, ECG ST segment changes, positive inotropic dosages, postoperative extubation time, ICU stay time and other projects; in the electric environment of myocardial ultrastructural changes were observed. Results There cTnI, CKMB, LDH, MYO gradually increased after the opening of the aorta was significantly higher than before the occlusion ( P lt;0.05). increases in these indicators were the experimental group than control group, cTnI, CKMB at 30 min after the aortic declamping and 6 h after CPB were significantly down compared with the control group (P lt;0.05), and experimental auto-recovery of heart jump rate, ST segment changes in the minor surgery, less inotropic medicine, ICU stay time is short; electron microscopy also showed that the ultrastructure of myocardial injury in experimental group was significantly lighter than the control group. Conclusions 1,6 - diphosphate in heart valve replacement with good myocardial protection. [Keywords:] heart valve replacement; 1,6 - diphosphate; CPB; myocardial protection Abstract: OBJECTIVE To evaluate protective effects of Fructose-1 ,6-bisphosphate (FDP) on myocardial structure and function d