Are concerned with radio Xiangdan injection on myocardial ischemia-reperfusion injury_0.docVIP

 PAGE \* MERGEFORMAT 9 Are concerned with radio Xiangdan injection on myocardial ischemia-reperfusion injury Of: Zhou Tingting, Li Shengtao, Feng Guifang, Liu row [Abstract] Objective To observe the attention to radio Xiangdan injection of preconditioning on myocardial ischemia-reperfusion injury. Methods rat left anterior descending coronary artery ligation to establish the roots of threading myocardial ischemia reperfusion injury model. Observe the ECG ST segment changes and myocardial tissue ET, NO, NOS levels and calculation of ET / NO ratio. Results ligation 30min, model group than in the control group was significantly ST segment elevation, reperfusion 30min, Hong Dan group than in model group, ECG ST segment depression was (P lt;0.05 ~ 0.01, Hong Dan, could significantly increase the myocardial tissue NOS activity and NO content (P lt;0.05 ~ 0.01, Hong Dan, could significantly decrease the content of myocardial tissue ET and ET / NO ratio (P lt;0.05 ~ 0.01. Matthiola Dan conclusions are concerned with pre-injection can reduce coronary vascular endothelial injury, inhibition of excessive contraction or relaxation of coronary vessels, regulate vasomotor function, against myocardial ischemia-reperfusion injury. [Keywords:] Xiangdan injection, within the customs points, myocardial ischemia and reperfusion Myocardial ischemia-reperfusion injury has been very concerned about domestic issues the medical profession, but also a hot research topic. This study was related by the Xiangdan injection point injection method of pretreatment, myocardial tissue ET, NO, NOS levels and Calculation of ET / NO ratio, the observed changes in ECG, of this Law on myocardial ischemia-reperfusion injury. 1 Materials and methods 1.1 Xiangdan experimental drug injection (National Tsing Hua University Dikang Hubei Pharmaceutical Co., Ltd., Zhunzi: batch number: 090115, CSDP (Tasly Pharmaceutical Co., Ltd., Zhunzi: batch number: 090621. 1.2 A