Aripiprazole treatment of mental disorders due to alcohol-control study.docVIP

 PAGE \* MERGEFORMAT 12 Aripiprazole treatment of mental disorders due to alcohol-control study Author: Lv Weizhong Sun Zheng-Ming Huang Jiwei Zhang 【Abstract】 Objective Aripiprazole treatment of mental disorders due to alcohol the clinical efficacy and safety. Methods 64 cases of alcohol-induced mental disorder were randomly divided into two groups of 32 cases were treated with aripiprazole and perphenazine in the treatment, course of 6 w. In the pre-treatment and treatment of 6 w end use of positive symptoms and negative symptoms scale, side effects rating scale of clinical efficacy and adverse reactions. Results 6 w end of the aripiprazole group were effective rate was 68.8%, efficiency 87.5%; perphenazine group were 62.5%, 81.3%. Positive Symptoms and Negative Symptoms Scale total score and each factor score of two groups of 6 w end of treatment than those before treatment there was a significant decrease (P all lt;0  01), but the aripiprazole compared with perphenazine group of negative symptoms sub - group decreased more significantly (P lt;0.05); aripiprazole group increased muscle tone, tremor, akathisia, and body mass gain and other adverse reactions was significantly lower than perphenazine group (P lt;0.05 or 0.01). Conclusions Aripiprazole treatment of mental disorders due to alcohol effect is significant, high security, compliance is good. Keywords: alcohol-induced mental disorders; Aripiprazole; perphenazine With the social and economic development, alcohol consumption has become a serious social problem, alcohol dependence and alcohol-induced mental disorder increasing. Studies have shown that [1,2], atypical antipsychotics such as olanzapine, risperidone in the treatment of mental disorders due to alcohol effect is significant. To this end, we apply due to alcohol aripiprazole in the treatment of mental disorders with perphenazine conducted a controlled study, will now report the results as follows. An object