Atorvastatin on Livin NFB and IL1 in cerebral ischemia of brain tissue.docVIP

 PAGE \* MERGEFORMAT 14 Atorvastatin on Livin NFB and IL1 in cerebral ischemia of brain tissue [Abstract] Objective cerebral ischemia in rat brain Livin, NF B and interleukin (IL 1 expression and the concept of atorvastatin on expression, of atorvastatin on cerebral ischemia-reperfusion protective mechanism of the brain. Methods suture method of middle cerebral artery ischemia reperfusion rat model, rats were randomly divided into sham operation group (S group, model group (M group and the atorvastatin treatment group (MT Group, Western blotting and RT PCR detection of rat brain Livin, NF B and the expression of IL 1, TTC staining, measured volume of cerebral infarction. Results infarct size MT group were significantly lower than M (P lt;0.05, compared with S group significantly higher (P lt;0.01, MT group NF B and IL 1 expression compared with M group decreased (P lt;0.05, MT group Livin expression compared with M group increased (P lt;0.05, MT group Livin, NF B, and IL 1 expression compared with S group increased (P lt;0.05, M group Livin, NF B, and IL 1 expression was significantly higher than the S group (P lt;0.01. Conclusions Atorvastatin can reduce cerebral ischemia and reperfusion in rat brain NF B and IL 1, enhanced Livin expression in brain cell apoptosis and inflammation play a role in brain protection. [Keywords:] ischemia reperfusion, atorvastatin, apoptosis, inflammation NF B is a widely present in eukaryotic cells, transcription factors, has confirmed that cerebral ischemia can activate NF B, NF B, directly or indirectly involved in mechanisms of cerebral ischemic injury in the process. Statin (statins) that 3 hydroxy-3-methyl glutaric acid mono-coenzyme A (HMG CoA) reductase inhibitors, are a class of powerful cholesterol-lowering drugs, these drugs can significantly regulate blood lipids in addition, also with multiple sexual anti-atherosclerosis role in prevention and treatment of cardiovascular and cerebrovascular disease has a wide ran