Axin and cell signal transduction research.docVIP

 PAGE \* MERGEFORMAT 12 Axin and cell signal transduction research [Keywords:] Axin gene [Keywords:] Axin gene; WNT signal transduction pathway; JNK signal transduction pathway; tumor inhibitor 0 Introduction Axin (axis inhibitor) gene in 1997, the Department of the natural mouse mutant gene cloning analysis of proteins found in the gene encoding AXIN, formerly known as FUSED, in order to avoid confusion with the unrelated Drosophila FUSED genes, and speculated FUSED gene in animal embryo body axis play an important role in differentiation will be renamed the AXIN, the axis suppression [1,2]. Axin can be found in many organisms in vivo is currently known that there are two members of the Axin family, Axin (Axin1) and its homolog Axil ( Axin like), also known as conductin or Axin2 [2]. genes were located on chromosome 16q133, 17q24 Department. Axin may be located in membrane, cytoplasm and nucleus, including a G protein signaling domain of the control section, C-side with Dishevelled protein, N terminal conserved sequence is highly homologous. Axin has more than one fixed domain, at least, and 18 kinds of protein interactions, as a scaffold protein to play a variety of biological functions. Axin several functional domains of the phosphorylation site a high degree of conservative. 1Axin with the WNT and JNK signal transduction pathway Axin 2 in the WNT and JNK signal transduction pathway plays a dual role. WNT and JNK signal transduction pathway is a series of oncogenes and tumor suppressor gene encodes a protein composed of a variety of proteins with each other, mutual restraint, thereby constituting a complex the signal transmission network. These signal transduction in cells of the growth, differentiation, maturity, individual developmental processes play an important role in the regulation, their abnormal signal transduction and tumor occurrence and is closely related to abnormal development of embryos. Axin has a series of protein binding sites, with W