Childrens Nanning City ApoB gene Xba I polymorphism analysis of.docVIP

 PAGE \* MERGEFORMAT 3 Children’s Nanning City ApoB gene Xba I polymorphism analysis of Author: Hu Peng Jing Cheng Xue Tan Yuan Han-Ping Chen Liming Fang Pei Juan [Abstract] Objective To study the physical examination of Nanning City, 126 healthy children, apolipoprotein B (ApoB) gene Xba I sites of the distribution of genotypes and explore its polymorphism on children’s growth, nutritional status, lipid metabolism and renal function in impact. Methods  polymerase chain reaction restriction fragment length polymorphism (PCR  RFLP) detected 126 cases of child health examination ApoB gene Xba I locus genotypes to calculate body mass index (BMI), serum total protein (TP) , albumin (AIB), globulin (GLO), albumin / globulin (A / G), lipoprotein a (LPa), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol ( HDL  C), non-high-density lipoprotein cholesterol (non  HDL), low-density lipoprotein cholesterol (LDL  C), apolipoprotein A1, (ApoA1), ApoB, ApoA1 / B, blood urea nitrogen (BUN), creatinine (Ccr) and uric acid (UA). Results (1) Xba I sites of the genotype frequencies were X-/X-: 92  06% (116/126), X / X-: 7.14% (9 / 126), X / X: 0.79% (1 / 126); allele frequency of X-and X were 95  63% and 4  37%; (2) allele X serum levels of TP, AIB, A / G and ApoA1 / B was significantly lower than X-group, and BMI, LPa, TC, TG, non  HDL, LDL  C, ApoB, BUN and Ccr significantly higher than X-group. Conclusion ApoB gene Xba I polymorphism of the children’s growth, nutritional status, affect lipid metabolism and renal function. [Keywords:] Apolipoprotein B; gene polymorphism; body mass index; total cholesterol; children Lipid metabolism in childhood not only with the growth and development, nutritional status and renal function is closely related to, but also adult cardiovascular disease (cardiovascular disease, CVD) indicate a major factor 〔 1〕 . Everaldo et al 〔 2〕 that children exposed to harmful environmental factors, more o