Chinese medicine treatment MMP9 TIMP1 and CA125 in the ectopic and eutopic endometrium expression.docVIP

 PAGE \* MERGEFORMAT 18 Chinese medicine treatment MMP9 TIMP1 and CA125 in the ectopic and eutopic endometrium expression [Abstract] Objective To investigate the medical treatment of adenomyosis and its mechanism. Methods 37 patients underwent hysterectomy in patients with adenomyosis before surgery were divided into treatment group (n = 17) and control group (n = 20) . eutopic endometrium as specimens, as ectopic endometrial adenomyosis specimens. determined by immunohistochemistry and compared the eutopic and ectopic endometrium of matrix metalloproteinase 9 (MMP 9) and tissue inhibitor of metalloproteinase agent 1 (TIMP 1) the expression level were observed before and after treatment of serum CA125. Results treatment group in the ectopic endometrial tissue, MMP 9 in the glandular epithelial cells was significantly lower than the control group ( P lt;0.05), TIMP 1 expression was significantly higher (P lt;0.05), MMP 9/TIMP 1 ratio was significantly lower than the control group (P lt;0.05). Medicines serum CA125 significantly decreased after treatment, and treatment before and control group differences were statistically significant (P lt;0.05). Conclusion medicine may be reduced by the ratio of MMP 9/TIMP 1 and lower levels of serum CA125 to control the invasion of ectopic endometrial tissue of the plant. [Keywords:] Chinese medicine, adenomyosis, matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1, CA125 ABSTRACT: Objective To study the mechanism of Chinese Medicine in treating adenomyosis. Methods Thirty seven patients in the Chinese Medicine treated group (17 cases of adenomyosis) and the control group (20 cases of adenomyosis, non drug treated) underwent hysterectomy. Endometrium was looked as eutopic endometrium and adenomyosis as ectopic endometrium. Expression of MMP 9 and TIMP 1 in eutopic and ectopic endometrium were measured by immunohistochemical techniques. Meanwhile the levels of CA125 in serum were measured. Results The