Chinese intervention mechanism of oxidative stress status of diabetic.doc

 PAGE \* MERGEFORMAT 11 Chinese intervention mechanism of oxidative stress status of diabetic [Keywords:] diabetes mellitus, oxidative stress, antioxidant, medicine, review In 2001, Brownlee [1] proposed and its vascular complications in type 2 diabetes have a common disease mechanisms - oxidative stress, as the culprit in diabetes and its chronic complications throughout the whole disease process. With modern medicine-related deepening of the study, the clinical treatment of antioxidant drugs has become chronic complications of diabetes and its hot, but were unable to completely block the oxidative stress pathway, whereas traditional Chinese anti-oxidants are increasingly being taken seriously. I now in recent years, Chinese medicine treatment oxidative excited to summarize current research. An enhanced antioxidant enzyme activity, reduce lipid peroxides So far, many studies have used detection of changes in antioxidant enzyme activities to evaluate the antioxidant effects of Chinese medicine, and malondialdehyde (MDA) is the detection of lipid oxidative damage in the most typical representative of [2], many clinical and antioxidant Antioxidant enzyme also used to detect the effect. 1.1 Single component Ma et al [3] of streptozotocin (STZ) induced diabetic rats were randomly divided into diabetic group, breviscapine group and aminoguanidine group, administration of 15 to 17 weeks after the rats kidney MDA , superoxide dismutase (SOD). The results showed that aminoguanidine can breviscapine and kidney tissue MDA were significantly decreased, SOD activity was significantly higher protective effect on the kidney, can delay the appearance of diabetic nephropathy. Chen [4] Fed the high fat, sugar + STZ injection caused by rat model of type 2 diabetes were divided into normal control group, diabetic group and valerian oil group, respectively, in the treatment of 11 weeks and 17 weeks of monitoring renal tissue MDA content and copper, Zn - supero