Chiral ruthenium complexes Δ[Ru (bpy) 2IPBP] 2 Synthesis and Cytotoxicity.docVIP

 PAGE \* MERGEFORMAT 14 Chiral ruthenium complexes Δ[Ru (bpy) 2IPBP] 2 Synthesis and Cytotoxicity Author: Wen-Jie Mei, Wang Na, Liu Jun, Ma Yuzhuo, Xie Hua-Song, Liang Baoxia [Abstract] Objective Δ  [Ru (bpy) 2 (py) 2] [o, o ‘ dibenzoyltartrate] * 12H2O and 3  formyl chromone as raw materials, preparation of chiral ruthenium polypyridyl complexes Δ  [Ru ( bpy) 2IPBP] 2 (Δ  1) (bpy = bipyridine, IPBP = 2  (4  toluene and pyran  2  ketone) imidazo [4,5  f] [1,10] phenanthroline), and In vitro anti-tumor activity of its preliminary evaluation. Methods of elemental analysis, electrospray ionization mass spectrometry (ESI  MS), nuclear magnetic resonance (NMR) and other target compounds were characterized, using MTT method preliminary study of the complex Δ  1 in human hepatocellular carcinoma cells Bel  7402, lung adenocarcinoma cells HCT  8 significantly inhibited. Results and Conclusion target compounds by elemental analysis, electrospray mass spectrometry results are basically consistent with the theoretical value; when the complex concentration of 50 μ g / mL, the complexes Δ  1 in human hepatocellular carcinoma cells Bel  7402, lung cancer cell HCT  8 significantly inhibited. [Keywords:] chiral; ruthenium (Ⅱ ) complexes; cytotoxicity; lung adenocarcinoma cell Abstract: Objective To preparation a novel chiral ruehtnium (II) complexes, Δ  [Ru (bpy) 2IPBP] 2 (Δ  1) (bpy = bipyridine, IPBP = 2  (4  methy  1  benzopyran) imidazo [4 , 5  f] [1,10] phenanthroline) and evaluate its antitumor activity. Methods The target compound Δ  1 was synthesized and characterized by elementary analysis, ESI  MS and 1H NMR, and the cytotoxicity of this ruthenium (II) complex Δ  1 against human hepatocarcinoma cell line Bel  7402 and human intestinal adenocarcinoma cell line HCT  8 and human lung adenocarcinoma epithelial cell line A  549 were also investigated by MTT methods. Results and conclusion The stud