Chronic kidney disease of bone mineral metabolism in the pathogenesis and therapy progress.docVIP

 PAGE \* MERGEFORMAT 18 Chronic kidney disease of bone mineral metabolism in the pathogenesis and therapy progress [Abstract] chronic kidney disease (CKD) is a variety of kidney disease in the acute phase of uncontrolled outcome of a group of common diseases, chronic kidney disease of bone mineral metabolism disorders (CKD MBD) is a common complication of CKD. In this paper, CKD MBD in the pathogenesis and treatment of research progress were reviewed. [Keywords:] chronic kidney disease; bone mineral metabolism; literature review Chronic kidney disease (CKD) is a variety of kidney disease in the acute phase of uncontrolled outcome of a group of common diseases, high incidence of serious harm to human health. CKD MBD is a common complication of CKD [1], including the traditional concept secondary hyperparathyroidism (SHPT), renal osteodystrophy and ectopic calcification. CKD MBD in patients with CKD (especially in maintenance hemodialysis patients), the prognosis is closely related to further clarify the pathogenesis of CKD MBD and how Improved treatment of CKD MBD is one of the focus in recent years. In this paper, CKD MBD in the pathogenesis and treatment of the research reviewed in the paper. 1 CKD MBD pathogenesis CKD CKD MBD is the progression of renal damage in the body’s calcium and phosphorus metabolism disorder leading a group of clinical syndromes, including SHPT, vascular, soft tissue calcification, bone turnover and bone mineral metabolic abnormalities such as [1]. CKD MBD’s disease Advances mechanisms to see from the current mainly related to calcium and phosphorus metabolism, PTH and vitamin D, and abnormal secretion of fibroblast growth factor 23 (FGF 23) and so on. 1.1 calcium and phosphorus metabolism and SHPT Normal plasma concentrations of calcium and phosphorus to maintain steady-state balance. CKD patients as their illness progresses, the kidneys produce a row of P and reduction of @-hydroxylase, resulting in high plasma