Chiral drugs and their progress in catalytic asymmetric synthesis of.docVIP

 PAGE \* MERGEFORMAT 14 Chiral drugs and their progress in catalytic asymmetric synthesis of [Abstract] This paper describes the importance of chiral drugs and types; with examples of catalytic asymmetric synthesis of chiral drugs for a brief overview, in particular, the chemical asymmetric catalysis, including asymmetric catalytic hydrogenation, catalytic asymmetric reduction of carbonyl groups , asymmetric oxidation, asymmetric cyclopropanation, and catalytic asymmetric carbonyl addition reactions such as asymmetric catalysis; prospect of catalytic asymmetric synthesis of chiral drugs in development. [Keywords:] chiral drugs; asymmetric catalytic reaction; synthesis Hands of the general features of the natural world. As an important basis for life activity of biological macromolecules, such as proteins, polysaccharides, nucleic acids and enzymes are almost all chiral. Chemicals commonly used in today’s world of chiral drugs accounted for more than 60% proportion of their in vivo pharmacological effects of macromolecules through the hands of match between the strict implementation of molecular recognition. In recent years, the world’s total sales of chiral drugs is also increasing, according to statistics, in 1995 to 425 billion U.S. dollars, 1997, 900 billion in 2000 has over 120 billion U.S. dollars [1], 2010, is expected to more than 250 billion U.S. dollars. As a huge market has attracted great academic and industry attention, and hand the rise in the international of the technology boom. 1 and pharmacological activity of chiral drugs In the generation and evolution of life, nature often have a preference for chiral, naturally occurring sugars such as D-configuration, L-configuration amino acids, proteins and DNA in the helical conformation and both are right-handed . So, when chiral drugs, pesticides and other compounds acting on the asymmetry of the biosphere, because their three-dimensional structure of molecules give rise to different in