Chronic lead exposure in mice pCREB protein expression in.docVIP

 PAGE \* MERGEFORMAT 9 Chronic lead exposure in mice pCREB protein expression in Authors: Wentao, Liu Yang, Li Sun light, tension, Zhao Xiaoguang, high minch, Zong Zhi, Liu Suyuan \ [Abstract] Objective To investigate the phosphorylation of lead on mouse hippocampal adenosine ring phosphorus ester (cAMP) response element-binding protein (pCREB) in rats. Methods Mice were born in the first 1d female mouse from the beginning of lead-exposed group fed through drinking water to 2  4,4  8,9  6mmol / L concentrations of lead acetate. Pups born, the first exposure to lead through breast-feeding, weaning and the female mouse after drinking on their own the same concentration of lead in drinking water. 14,28,42,56 d mice were killed, respectively, using protein blot in hippocampus of mice in each group observed pCREB protein expression. The results of chronic lead exposure in mice hippocampus pCREB protein expression in the overall downward trend, compared with the control group, 2  4mmol / L of lead exposure to 14d in mice pCREB protein expression increased, but the difference was not statistically significant (Pamp;gt; 0  05); and 4  8,9  6mmol / L of lead exposure group pCREB protein expression has been maintained at a relatively low level, the difference was statistically significant (P amp;lt;0  05). Conclusions lead to disrupt the normal expression of pCREB protein. [Keywords:] Lead Lead is the most widely used industrial metal, one widespread in nature, the living environment in the life of lead pollution posed a serious threat to human health, especially children, lead poisoning prevalence rates much higher than adults, significant effect on children’s mental development. This study was designed by observing the hippocampus of mice with chronic lead acetate exposure phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein (pCREB) expression to explore the molecular mechanism of chronic lead poisoning. 1 Mater