Clarithromycin sustained-release tablets in different release media release of.docVIP

 PAGE \* MERGEFORMAT 15 Clarithromycin sustained-release tablets in different release media release of Of: Wang Xiaoling, Liangchao Feng, Xie Zhihong, Zhou Tao, Huang Ji [Abstract] Objective To study the self-made and commercially available sustained release tablets of clarithromycin in different release media release to analyze the in vitro release behavior. Method reference both the Chinese Pharmacopoeia and the United States Pharmacopoeia dissolution method of self-determination by HPLC with the commercial release clarithromycin tablets, and the release model and f2 similarity factor were compared. Results BIAXIN XL for the reference preparation, self-release tablets in the two conditions, f2 values were more than 50 to KLACID MR as the reference preparation, self-release tablets in the two conditions, f2 values were less than 50. Conclusions The sustained release tablet and a commercially available BIAXIN XL similar in vitro release behavior. [Keywords:] release clarithromycin tablets similar to factor Abstract: Objective To study the dissolution of clarithromycin sustained release tablets in different media and analyze their dissolution behavior in vitro. Methods Comparison of CHP2005 and USP31 two different dissolution methods, the dissolution of self prepared and imported clarithromycin sustained release tablets were determined by HPLC, their kinetics model and similarity factor (f2 value) were compared. Results BIAXIN XL was used as reference preparation, f2 value of self prepared sustained release tablets was more than 50 in two different dissolution conditions. When KLACID MR was used as reference preparation, f2 value was less than 50 in two different dissolution conditions. Conclusion The dissolution behavior of BIAXIN XL of self prepared and imported clarithromycin sustained release tablets was consistent in vitro. Keywords:: Clarithromycin, sustained release tablets, dissolution Clarithromycin (clarithromycin, CLM) is a macroli