Clindamycin clinical side effects and control measures.docVIP

 PAGE \* MERGEFORMAT 5 Clindamycin clinical side effects and control measures Keywords:: clindamycin; the clinical side-effects; preventive measures Abstract Lincomycin Clindamycin for the derivatives market in China since 1970, there have been 20 years of history, in the application of the most common adverse reactions: allergic reactions, injection site irritation and liver function abnormalities, the most serious is pseudomembranous colitis (PMC). Recent reports of domestic clindamycin phosphate 9.4% incidence of adverse reactions [2], in the secondary lung cancer after radiotherapy in patients with anaerobic infections in the incidence of adverse reactions was 22% [3]. To prevent and reduce the occurrence of clindamycin side effects in clinical treatment has become an important issue. Keywords: clindamycin; the clinical side-effects; preventive measures Clindamycin is a derivative of lincomycin, since 1970 in China’s market, there have been 20 years of history, in the application of the most common adverse reactions: allergic reactions, injection site irritation and abnormal liver function, the most seriously, pseudomembranous colitis (PMC). 1 The clinical side effects of clindamycin 1.1 The reaction of the gastrointestinal tract gastrointestinal tract the most common response is clindamycin, the highest incidence of response, oral and intramuscular injection can occur. Manifested as nausea, vomiting, anorexia, abdominal distension, diarrhea, abdominal pain and other symptoms of pseudomembranous colitis (PMC) caused the most serious complications. The incidence of diarrhea due to differences in diagnosis of various large, about 2% ~ 20%, commonly found in medication after 4 ~ 9h, may be related to drugs and the direct stimulation of the normal intestinal flora disturbance. Simple diarrhea and PMC is not relevant to whether or not there, the former are usually brief, timely withdrawal is generally self-healing.