Clinical diagnosis and treatment of Diabetic Gastroparesis Chinese Experience.docVIP

 PAGE \* MERGEFORMAT 8 Clinical diagnosis and treatment of Diabetic Gastroparesis Chinese Experience [Keywords:] diabetes mellitus; gastroparesis; Diabetes, fullness Diabetic gastroparesis (diabetic gastroparesis, DGP also known as diabetic gastric retention or gastric paralysis [1]. The major clinical manifestations as decreased gastric motility, emptying delay, or even to reduce gastric acid secretion, mucosal atrophy, may have upper abdominal fullness , swelling of the liver, nausea, pain, accompanied by intractable nausea, vomiting and other symptoms. 1 Pathogenesis Pathogenesis of diabetic gastroparesis is unclear, mainly that the and autonomic neuropathy, hyperglycemia, gastrointestinal disorders, hormonal factors [2] related. (1 autonomic nerve and internal nerve lesions. Autonomic neuropathy in the DGP’s play an important role in the pathogenesis of diabetic patients with autonomic neuropathy was 20% to 40%, mainly nerve cell degeneration, the vagus nerve demyelination was phased so that the basic electric rhythm spread of gastric slow gastric contractions decreased tension , decreased gastric motility, delayed gastric emptying. (2 high blood sugar. gastric emptying by the movement and adjust the impact of blood glucose levels, high blood sugar reduced gastric motility, induced contraction of isolated antral waves, induced gastric dysrhythmia, changes in gastric compliance, thereby reducing the gastric emptying. (3 gastrointestinal hormone imbalance. gastrointestinal hormones motilin, gastrin, glucagon, somatostatin and so may affect gastrointestinal motility, hormone secretion in patients with gastrointestinal tract abnormalities, such as: elevated levels of glucagon, inhibition of motility, decreased gastric contractility. (4Cajal cells decreased. Cajal are pacemaker cells in the gastrointestinal tract, resulting in slow and control the slow conduction . Cajal cells in diabetic patients reduce the number of gap junctions between reduced, r