Clozapine in 30 years of clinical experience.docVIP

 PAGE \* MERGEFORMAT 10 Clozapine in 30 years of clinical experience [Abstract] Objective clinical application of clozapine. Methods paper published nearly 10 articles, refer to the literature, according to clinical practice. The results showed that the clinical indication for clozapine, clinical efficacy, patient medication usage frequency, therapeutic dose , side effects, etc., that clozapine induced agranulocytosis was significantly lower than 12 years ago. Conclusions long-term use of clozapine is relatively safe, but agranulocytosis, disturbance of consciousness and other side effects, not to relax their vigilance, the need for regular blood examination and observation, and reporting of their families. [Keywords:] side effects dose clinical efficacy of clozapine [Abstract] Objective To research the clinical application of clozapine. Methods 10 articles and reference literature published by us were investigated and studied. Results Agranulocytosis caused by clozapine decreased obviously than 12 years ago according its clinical indication, curative effect, hospitalization medication frequency, therapeutic dose and side effect. Conclusion Long-term application of clozapine is safe except for causing agranulocytosis and conscious disturbance. We need inform the families and inspect hemogram regularly. [Keywords:] clozapine; clinic; curative effect; dosage; side reaction; experience Since its inception in 1966, clozapine, have 40 years. Foreign addition to Finland, Denmark, has been widely used outside. Since 1976, use of clozapine have 30 years. The author has published in 1984, “Clozapine report of 106 cases of schizophrenia treatment “[1], and then also reported a” clozapine and agranulocytosis “[2],” Effects of clozapine and agranulocytosis investigation report, “[3],” application of clozapine The years of clinical experience “[4],” and then on clozapine and agranulocytosis “[5],” due to clozapine in patients with schizophrenia EEG analysis