Concurrent radiotherapy and chemotherapy for advanced cervical cancer.docVIP

 PAGE \* MERGEFORMAT 3 Concurrent radiotherapy and chemotherapy for advanced cervical cancer Author: Liu Shaobing, Tsu-Jin, Chen Sen, Tan Ruiping [Abstract] Objective To observe the chemotherapy combined with radiotherapy for advanced cervical cancer clinical efficacy and side effects. Methods 58 patients with advanced cervical cancer patients were randomly divided into groups of discharge (29 cases) and radiotherapy alone group (29 cases), place-based group received cisplatin 25mg/m2 d1  3, intravenous drip, 5  Fu 350mg/m2 d1  5 intravenous drip, repeated every 4 weeks, a total of three cycles, at the same time radical radiotherapy, chemotherapy, day 1 to begin radiotherapy. 10MVX line with the whole basin in vitro irradiation DT38 ~ 40Gy, the middle block of lead after the dose of radiation-induced Gongpang DT50 ~ 55Gy, the first three weeks starting line of 192Ir endovascular irradiation, 6Gy / times / day / week, A point dose 6Gy, B point dose 5Gy, a total of 6 ~ 7 times. Radiotherapy alone group, only line of radiotherapy, methods of assimilation RT group, no chemotherapy. The results of radiotherapy effective the end of the two groups were 96.6% and 86.2%, no significant difference (Pamp;gt; 0.05). 3 months after radiotherapy when the two groups were 96.6% effective and 65.5%, significantly different (P amp;lt;0.05). Radiochemical group of 3,5-year survival rates and tumor-free survival rates were 79.3%, 68.9%, 62.1%, higher than the radiotherapy alone group 62.1%, 51.7%, 41.4%, significantly different (P amp;lt;0.05), follow-up 5 years, put groups of pelvic recurrence rate was 17.2%, lower than the radiotherapy alone group of 31.0%, P amp;lt;0.05. Placed group of obvious bone marrow suppression and gastrointestinal reactions, but patients after treatment can be tolerated. Conclusion chemotherapy combined with radiotherapy for advanced cervical cancer can enhance efficacy, side effects of slightly increased, but patient can tolerate. [Keywords: