Consumer silt Danshensu Jiangzhi Capsule Dissolution study of sodium.docVIP

 PAGE \* MERGEFORMAT 10 Consumer silt Danshensu Jiangzhi Capsule Dissolution study of sodium Authors: Luo-sheng, Tsai Wen, Yang Qingsong, Wu Yonghong, Tan Rong Gui [Abstract] Objective To eliminate silt Danshensu Jiangzhi Capsule dissolution of sodium were measured in order to control its intrinsic quality. Methods rotating basket method, in order to high-performance liquid chromatography (HPLC) determination of Danshensu sodium as an indicator of consumer silt Danshensu Jiangzhi Capsule dissolution of sodium were measured. The results with 0.5% poly-resin 80 Yamanashi phosphate buffer solution as the dissolution medium, rotation speed 150 r / min, using Elite Hypersil C18 column (5μ m, 25cm * 4.6mm), acetonitrile and potassium dihydrogen phosphate -10% -1% tetrabutylammonium hydroxide Ammonium (10:87:2.5) as mobile phase, flow rate: 1.0 ml * min-1, detection wavelength 281 nm, column temperature 40 ℃ , injection volume 10 μ l. The average recovery of 100.6% (RSD 0.44%), dissolution of the labeled amount of more than 70.0%. Conclusion HPLC Determination of extinction silt Jiangzhi Capsules Danshensu sodium is to control the inherent quality of the preparation of a simple, rapid and feasible approach. [Keywords:] Consumer silt Jiangzhi capsule; Salvia sodium; dissolution; high performance liquid chromatography Abstract: ObjectiveTo determine the dissolutions of sodium-tanshinol in Xiaoyujiangzhi Capsules in order to analyze its inner quality.MethodsWith rolling basket method, the content of sodium-tanshinol determined by HPLC was used to assess the dissolution of sodium-tanshinol in Xiaoyujiangzhi capsules.Results0 .5% Polysorbate 80 PBS was used as solvent. Rolling basket method was used with rotation rate of 150r/min for 120min; Elite Hypersil C18 Column (5 μ m, 25 cm * 4.6 mm) was used with AN-1% KDP-10 % quadr-Bu-ammonium hydroxide as mobile phase, the flow rate was 1.0 ml * min-1, detection wavelength was 281nm, column temperature was 40 ℃ , and the s