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Curcumin solubilization Comparative Study of
PAGE \* MERGEFORMAT 8
Curcumin solubilization Comparative Study of
Author: Han Gang Sun Guangli Kong Jingjing Zhang Weiguo
[Abstract] Objective To optimize the best way to improve the solubility of curcumin and conditions. Methods polyvinylpyrrolidone K30, polyethylene glycol 6000 as a carrier of solid dispersion preparation of curcumin; with β -cyclodextrin, 2 - hydroxypropyl-β -cyclodextrin inclusion compound of curcumin for material preparation. Determination of the solubility of these substances and in vitro dissolution. The results with PVP as a carrier of solid dispersions prepared by curcumin solubility in artificial intestinal juice the most, along with the increase in the amount of PVP to join, curcumin dissolution faster. Conclusion Preparation of PVP as a carrier of solid dispersions of curcumin Curcumin solubilization the best results.
[Keywords:] curcumin; solid dispersion; inclusion; dissolution
Abstract: ObjectiveTo optimize the best increasing dissolution condition of curcumin. MethodsThe solid dispersion of curcumin were prepared with PVP (K30) and PEG-6000; include compound of curcumin were prepared with β -CD and HP-β -CD. ResultsThe dissolution of solid dispersion of curcumin with PVP was the best and the rate of dissolution was fast than the others. ConclusionThe solid dispersion of curcumin with PVP is potent in improving the dissolution of curcumin.
Keywords:: Curcumin; Solid dispersion; Include compound; Dissolution
Curcumin (Cur) is a traditional Chinese medicine active ingredients in turmeric, has anti-tumor, anti-inflammatory, antioxidant, antibacterial, nourish the liver and a variety of pharmacological activities [1]. In recent years, the pharmacological effects of curcumin is more coverage, but the few reports of curcumin preparations. The main reason is curcumin is almost insoluble in water, the body absorb the poor, curcumin instability readily biodegradable [2]. In this study, polyvinylpyrrolidone (PVP), polyethylene gl
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